Flexible dosing to optimize tolerability and response1

Dosing Calculator

Select a recommended dosage or enter a custom dosage

Recommended dosage1

*NOTE: Total dosage should be split and administered twice daily.
See additional dosing considerations for more information.

mg/kg/day
WEEK 11

Start EPIDIOLEX with 5 mg/kg/day (2.5 mg/kg twice daily)

WEEK 21

Dosage can increase to a recommended maintenance dosage of 10 mg/kg/day (5 mg/kg twice daily)

If tolerated and required1:

Increase in weekly increments of 5 mg/kg/day (2.5 mg/kg twice daily), up to 20 mg/kg/day

*Additional dosing considerations1
  • For patients in whom a more rapid titration from 10 mg/kg/day to 20 mg/kg/day is warranted, the dosage may be increased no more frequently than every other day
  • Administration of the 20 mg/kg/day dosage resulted in somewhat greater reductions in seizure rates than the recommended maintenance dosage of 10 mg/kg/day, but with an increase in adverse reactions

See dosing for
hepatic impairment

Results

A total daily dosage of X.X mL (XX mg) of EPIDIOLEX to be taken in twice daily doses of X.X mL

For a weight of XX kg and a target total daily dosage of XX mg/kg/day, the patient should take X.XX mL orally twice daily

Download your patient's dosage

Dosing Calculator

Select level of hepatic impairment

Select a recommended dosage or enter a custom dosage

Recommended dosage1

*NOTE: Total dosage should be split and administered twice daily.
See additional dosing considerations for more information.

mg/kg/day
*Additional dosing considerations1
  • Because of an increase in exposure to EPIDIOLEX, dose adjustment and slower dose titration is recommended in patients with moderate or severe hepatic impairment. Consider not initiating EPIDIOLEX in patients with
 evidence of significant liver injury. Dose adjustments are not required in patients with mild hepatic impairment

Review additional
monitoring considerations

Results

A total daily dosage of X.X mL (XX mg) of EPIDIOLEX to be taken in twice daily doses of X.X mL

For a weight of XX kg and a target total daily dosage of XX mg/kg/day, the patient should take X.XX mL orally twice daily

Download your patient's dosage

User Local Time
Patient Weight

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Please note that the volume may be rounded to accurately measure the dose with the syringes that are provided with EPIDIOLEX.

The content on the results is intended for US healthcare professionals only and should only be applied to EPIDIOLEX (cannabidiol). The information provided is not intended to supersede independent clinical judgment or institutional protocols.

Dosing in patients with hepatic impairment1


Epidiolex Dosage for Patients with Moderate and Severe Hepatic Impairment Epidiolex Dosage for Patients with Moderate and Severe Hepatic Impairment

Writing a prescription? Find specialty pharmacies in your area that provide EPIDIOLEX


Food may affect EPIDIOLEX levels1

EPIDIOLEX is an oral solution that is compatible with a ketogenic diet.
EPIDIOLEX should be administered consistently with respect to meals.

Epidiolex Cannabidiol Prescription Example
Epidiolex Cannabidiol Prescription Example - Titration
Epidiolex Cannabidiol Prescription Example - Maintenance

*This is provided for example purposes only. Not intended to supersede independent clinical judgment or institutional protocols. Please see full Prescribing Information for recommendations on liver monitoring.

As certain health plans and institutions may have policies regarding cannabinoid products/use, prescriptions should include EPIDIOLEX by name to avoid rejection.

If dose adjustment is required mid-prescription cycle, a new prescription will be needed.

 


Other dose adjustment considerations1

  • EPIDIOLEX causes dose-related elevations of liver transaminases. Because of the risk of hepatocellular injury, obtain serum transaminases (ALT and AST) and total bilirubin levels in all patients prior to starting treatment with EPIDIOLEX and periodically thereafter
  • Because of an increase in exposure to EPIDIOLEX, dose adjustment and slower dose titration is recommended in patients with moderate or severe hepatic impairment. Consider not initiating EPIDIOLEX in patients with evidence of significant liver injury. Dose adjustments are not required in patients with mild hepatic impairment
  • Moderate or strong inhibitors or inducers of CYP3A4 and CYP2C19 may affect EPIDIOLEX exposure. EPIDIOLEX may affect exposure to CYP2C19 substrates (eg, clobazam, diazepam) or others. Concomitant use of EPIDIOLEX and valproate increases the incidence of liver enzyme elevations. Dosage adjustment of EPIDIOLEX or other concomitant medications may be necessary
SEE ADDITIONAL
CONSIDERATIONS

EPIDIOLEX was studied in refractory patients with LGS or Dravet syndrome taking multiple concomitant AEDs1

SEE BASELINE CHARACTERISTICS

Reference 1: EPIDIOLEX [package insert]. Carlsbad, CA: Greenwich Biosciences, Inc.; 2018.