EPIDIOLEX® (cannabidiol) offers flexible dosing for tolerability and response optimization1

Calculate your patient's dosage by selecting a recommended dose below or entering a custom dose

RECOMMENDED DOSING AND TITRATION

Increase in weekly increments of 5 mg/kg/day (2.5 mg/kg twice daily)*

Dose adjustment and a slower dose titration are recommended in patients with moderate or severe hepatic impairment. Select an option above to view dosing recommendations for patients with hepatic impairment.

DS=Dravet syndrome.

*For patients in whom a more rapid titration is warranted, the dosage may be increased no more frequently than every other day.

For patients with LGS or Dravet syndrome, administration of the 20 mg/kg/day dosage resulted in somewhat greater reductions in seizure rates than the recommended maintenance dosage of 10 mg/kg/day, but with an increase in adverse reactions. Increase dose from 10 mg/kg/day if tolerated and required.

The effectiveness of doses lower than 25 mg/kg/day has not been studied in patients with TSC.

Because of an increase in exposure to EPIDIOLEX, dose adjustment and slower titration are recommended in patients with moderate or severe hepatic impairment. Consider not initiating EPIDIOLEX in patients with evidence of significant liver injury. Dose adjustments are not required in patients with mild hepatic impairment.

Review additional monitoring considerations

RECOMMENDED DOSAGE AND TITRATION — 1/2 STANDARD DOSING*

DS=Dravet syndrome.

*NOTE: Total dosage should be split and administered twice daily. See additional dosing considerations for more information.

Because of an increase in exposure to EPIDIOLEX, dose adjustment and slower titration are recommended in patients with moderate or severe hepatic impairment. Consider not initiating EPIDIOLEX in patients with evidence of significant liver injury. Dose adjustments are not required in patients with mild hepatic impairment.

Review additional monitoring considerations

RECOMMENDED DOSAGE AND TITRATION — 1/5 STANDARD DOSING*

DS=Dravet syndrome.

*NOTE: Total dosage should be split and administered twice daily. See additional dosing considerations for more information.

mg/kg/day

Results

A total daily dosage of X.X mL (XX mg) of EPIDIOLEX to be taken in twice-daily doses of X.X mL.

For a weight of XX kg and a target total daily dosage of XX mg/kg/day, the patient should take X.XX mL orally twice daily.

Download dosage

Please note that the volume may be rounded to accurately measure the dose with the syringes that are provided with EPIDIOLEX.

The content on the results is intended for US healthcare professionals only and should only be applied to EPIDIOLEX (cannabidiol). The information provided is not intended to supersede independent clinical judgment or institutional protocols.

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Other dosing considerations

  • Fork and Knife Diet Icon
    Food may affect EPIDIOLEX levels: EPIDIOLEX is an oral solution that is compatible with a ketogenic diet. EPIDIOLEX should be administered consistently with respect to meals. When necessary, EPIDIOLEX can be enterally administered via feeding tubes, such as nasogastric or gastrostomy tubes. Do not use with tubes made of polyvinyl chloride (PVC).
  • Liver Icon
    EPIDIOLEX causes dose-related elevations of liver transaminases: Because of the risk of hepatocellular injury, obtain serum transaminases (ALT and AST) and total bilirubin levels in all patients prior to starting treatment with EPIDIOLEX and periodically thereafter.
    • Because of an increase in exposure to EPIDIOLEX, dose adjustment and slower dose titration are recommended in patients with moderate or severe hepatic impairment. Consider not initiating EPIDIOLEX in patients with evidence of significant liver injury. Dose adjustments are not required in patients with mild hepatic impairment
  • Flexible Treatment Bottle and Syringe Icon
    Taking EPIDIOLEX with other drugs: Strong inducers of CYP3A4 and CYP2C19 may affect EPIDIOLEX exposure. EPIDIOLEX may affect exposure to CYP2C19 substrates (eg, clobazam, diazepam) or others. Concomitant use of EPIDIOLEX and valproate increases the incidence of liver enzyme elevations. No drug interaction studies have been completed, but case reports suggest a potential for elevations of mammalian target of rapamycin (mTOR) or calcineurin inhibitors when used with EPIDIOLEX. Dosage adjustment of EPIDIOLEX or other concomitant medications may be necessary.
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Administering EPIDIOLEX

Step-by-step instructions for administration.

Administration Video Thumbnail

Administering EPIDIOLEX1

Step-by-step instructions for administration
Reference: 1. EPIDIOLEX [package insert]. Carlsbad, CA: Greenwich Biosciences, Inc.; 2020.

Help patients get started with Preparation and Administration resources

Writing a prescription

Epidiolex Cannabidiol Prescription Example
Epidiolex Cannabidiol Prescription Example

This is provided for example purposes only. Not intended to supersede independent clinical judgment or institutional protocols. Please see full Prescribing Information for recommendations on liver monitoring.

As certain health plans and institutions may have policies regarding cannabinoid products/use, prescriptions should include EPIDIOLEX by name to avoid rejection.

If dose adjustment is required mid-prescription cycle, a new prescription will be needed.

This is provided for example purposes only. Not intended to supersede independent clinical judgment or institutional protocols. Please see full Prescribing Information for recommendations on liver monitoring.

Writing a prescription? Look up specialty pharmacies in your area that provide EPIDIOLEX

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