Early diagnosis and monitoring can make all the difference for patients with TSC-associated seizures

Epilepsy impacts most patients with TSC, and may often have devastating consequences1-4

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Epilepsy affects 70% to 90% of patients with TSC1,2

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A greater likelihood of developmental disabilities is correlated with epileptic spasms, a history of seizures, greater seizure frequency, earlier seizure onset, and pharmacoresistant epilepsy3,5

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Among patients with TSC, those with TSC-associated epilepsy have a worse health-related quality of life and cognitive deficits4

After just one seizure, patients with TSC have a nearly 100% chance of developing recurring seizures3

Guidelines recommend that parents should be educated to recognize TSC-associated seizures, which can be highly variable3,6,7

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Initial events may often begin as subtle EEG changes or seizures, which may easily be overlooked by parents2,8,9

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  • Partial-onset seizures, also known as focal seizures, are likely to be encountered in over 2/3 of patients during infancy7

    • Partial-onset seizures can be seen with or without impairment of awareness or can progress to generalized seizures10

  • Infantile spasms may occur in 38% to 47% of patients7

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Patients will likely progress to more than one seizure type, including7,11:

  • Partial-onset seizures

  • Atonic

  • Tonic

  • Clonic

  • Tonic-clonic

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12% of patients with TSC may develop seizures in adulthood3,5

It is not uncommon for patients to receive a diagnosis of TSC in adolescence or adulthood3,12

Experts recommend obtaining a baseline EEG and monitoring in all patients with a TSC diagnosis, even in the absence of recognized or reported clinical seizures6,9

Despite trial of multiple AEDs, many patients with TSC may continue to experience refractory seizures7,13

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After one AED, 64% of patients will eventually initiate 3 or more AEDs in search of seizure reductions—and 35% try 5 or more for their TSC-associated epilepsy13

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More than 1 in 3 patients who have surgery for their epilepsy will undergo multiple procedures13

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In a large TSC study,
partial-onset seizures remained uncontrolled in
38% of patients7

Have your patients with TSC been waiting for a new option for their TSC-associated seizures?