EPIDIOLEX (cannabidiol) is a first-in-class AED for the treatment of seizures associated with LGS or Dravet syndrome in patients 2 years and older1

Flexible dosing allows for individualization of treatment to maximize tolerability and response2

  • 8 daysA therapeutic dose can be achieved as early as Day 8

Dosing Calculator

Select a recommended dosage or enter a custom dosage

Recommended dosage

* NOTE: Total dosage should be split and administered twice daily.

See additional dosing considerations for more information.

mg/kg/day
Week 1

Start EPIDIOLEX with 5 mg/kg/day (2.5 mg/kg twice daily)

Week 2

Dosage can increase to a recommended maintenance dosage of 10 mg/kg/day (5 mg/kg twice daily)

If tolerated and required:

Increase in weekly increments of 5 mg/kg/day (2.5 mg/kg twice daily), up to 20 mg/kg/day

*Additional dosing considerations
  • For patients in whom a more rapid titration from 10 mg/kg/day to 20 mg/kg/day is warranted, the dosage may be increased no more frequently than every other day
  • Administration of the 20 mg/kg/day dosage resulted in somewhat greater reductions in seizure rates than the recommended maintenance dosage of 10 mg/kg/day, but with an increase in adverse reactions

See dosing for hepatic impairment

Results

A total daily dosage of X.X mL (XX mg) of EPIDIOLEX to be taken in twice daily doses of X.X mL

For a weight of XX kg and a target total daily dosage of XX mg/kg/day, the patient should take X.XX mL orally twice daily.

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Dosing Calculator

Select level of hepatic impairment

Select a recommended dosage or enter a custom dosage

Recommended dosage

* NOTE: Total dosage should be split and administered twice daily.

See additional dosing considerations for more information.

mg/kg/day
See full hepatic impairment dosing instructions below
*Additional dosing considerations
  • Because of an increase in exposure to EPIDIOLEX, dose adjustment and slower dose titration is recommended in patients with moderate or severe hepatic impairment. Consider not initiating EPIDIOLEX in patients with evidence of significant liver injury. Dose adjustments are not required in patients with mild hepatic impairment

Review additional monitoring considerations

Results

A total daily dosage of X.X mL (XX mg) of EPIDIOLEX to be taken in twice daily doses of X.X mL

For a weight of XX kg and a target total daily dosage of XX mg/kg/day, the patient should take X.XX mL orally twice daily.

Download PDF

Please note that the volume may be rounded to accurately measure the dose with the syringes that are provided with EPIDIOLEX. Not intended to supersede independent clinical judgment or institutional protocols.